Click Chemistry in Ultra‐high Vacuum – Tetrazine Coupling with Methyl Enol Ether Covalently Linked to Si(001)

The additive-free tetrazine/enol ether click reaction was performed in ultra-high vacuum (UHV) with an enol group covalently linked to a silicon surface: Dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate molecules were coupled the of functionalized cyclooctyne which adsorbed on (001) surface via strained triple bond cyclooctyne. observed at substrate temperature 380 K by means X-ray photoelectron spectroscopy (XPS). A moderate energy barrier deduced for this density functional theory based calculations, good agreement experimental results. This UHV-compatible thus opens new, flexible route synthesizing bound organic architectures.